肠道微生物源性脱氧胆酸形成免疫抑制肿瘤微环境并促进乳腺癌进展

肠道微生物源性脱氧胆酸形成免疫抑制肿瘤微环境并促进乳腺癌进展

作者： 小柯机器人 发布时间：2026/5/13 17:31:14

本期文章：《细胞—代谢》：Online/在线发表

2026年5月12日，浙江大学医学院邱福铭课题组在《细胞—代谢》杂志发表论文，宣布他们的最新研究揭示了肠道微生物源性脱氧胆酸形成免疫抑制肿瘤微环境并促进乳腺癌进展。

该研究团队报道肠道细菌Enteroclosterbolteae是毛螺科的一员，在肿瘤发展过程中逐渐富集，并与微生物衍生的代谢物脱氧胆酸水平升高有关。去氧胆酸在肿瘤中蓄积，激活肿瘤细胞中的法内甾体X受体，通过核因子κB信号通路诱导白细胞介素-6的产生。白细胞介素-6促进粒细胞髓源性抑制细胞和T辅助细胞17的募集，建立免疫抑制微环境。抑制或敲低法内甾体X受体，以及阻断白细胞介素-6信号，可减弱这些作用。这些发现确定了驱动乳腺癌进展的微生物-代谢物-免疫轴，并揭示了微生物代谢物作为潜在的治疗靶点。

研究人员表示，肠道微生物群越来越被认为是乳腺癌进展的一个因素。

附：英文原文

Title: Gut microbiota-derived deoxycholic acid shapes an immunosuppressive tumor microenvironment and promotes breast cancer progression

Author: Lili Li, Chenghui Yang, Zhen Wang, Bangyi Zhou, Yixin Zhang, Huiying Liu, Shanshan Sun, Mengyao Chen, Xiaoxiao Hu, Fang Jia, Sangsang Zhu, Miner Shao, Jun Pan, Leyi Zhang, Xinyi Zhang, Shuyan Yuan, Jingxuan Zhu, I. Situ, Jian Huang, Fuming Qiu

Issue&Volume: 2026-05-12

Abstract: The gut microbiota is increasingly recognized as a contributor to breast cancer progression. Here, we report that the gut bacterium Enteroclosterbolteae, a member of the Lachnospiraceae family, is progressively enriched during tumor development and is associated with increased levels of the microbiota-derived metabolite deoxycholic acid. Deoxycholic acid accumulates in tumors and activates the farnesoid X receptor in tumor cells, inducing interleukin-6 production through nuclear factor κB signaling. Interleukin-6 promotes the recruitment of granulocytic myeloid-derived suppressor cells and T helper 17 cells, establishing an immunosuppressive microenvironment. Inhibition or knockdown of the farnesoid X receptor, as well as blockade of interleukin-6 signaling, attenuates these effects. These findings identify a microbiota-metabolite-immune axis driving breast cancer progression and uncover microbial metabolites as potential therapeutic targets.

DOI: 10.1016/j.cmet.2026.04.011

Source: https://www.cell.com/cell-metabolism/abstract/S1550-4131(26)00149-X

主题：乳腺癌进展