植物细胞壁-质膜附着物通过纤维素合酶复合物和再凝蛋白介导逆境恢复
植物细胞壁-质膜附着物通过纤维素合酶复合物和再凝蛋白介导逆境恢复
作者： 小柯机器人 发布时间：2026/6/3 17:02:04
本期文章：《细胞》：Online/在线发表
斯坦福大学José R. Dinneny团队的研究认为植物细胞壁-质膜附着物通过纤维素合酶复合物和再凝蛋白介导逆境恢复。这一研究成果发表在2026年6月2日出版的国际学术期刊《细胞》上。
研究小组确定了两种控制壁膜附着的机制：一种依赖于纤维素合酶复合体（CSC），其在质膜上的密度与对高渗胁迫的抵抗力呈正相关，另一种依赖于雷莫林（REM），它对CSC机制起拮抗作用。利用接近标记蛋白质组学，该课题组发现SHOU4/4L是REM相关蛋白，介导这种拮抗作用。总之，他们的发现揭示了壁膜附着是如何调节植物细胞在水分胁迫下的恢复能力的。
据悉，生物体的外细胞表面是检测和响应环境刺激的前线。在植物中，这种界面由位于细胞壁下方的质膜组成，并通过附着位点与细胞壁保持联系。在高渗透性休克时，当严重的失水导致膜从壁上缩回时，这些壁膜附着物变得明显。尽管他们长期观察，这些附着物的分子身份和功能仍然知之甚少。
附：英文原文
Title: Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins
Author: Yue Rui, Magda Zaoralová, William P. Dwyer, Andres V. Reyes, Tarabryn S. Grismer, Nikolaj B. Abel, Dharanidaran Jayachandran, Shishir P.S. Chundawat, Thomas Ott, Joseph J. Kieber, Peter D. Dahlberg, Shou-Ling Xu, José R. Dinneny
Issue&Volume: 2026-06-02
Abstract: The outer cell surface of an organism is the frontline for detecting and responding to environmental stimuli. In plants, this interface consists of the plasma membrane that lies beneath the cell wall and remains associated with it through attachment sites. These wall-membrane attachments become evident upon hyperosmotic shock, when severe water loss causes the membrane to retract from the wall. Despite their long-standing observation, the molecular identity and function of these attachments remain poorly understood. Here, we identified two mechanisms governing wall-membrane attachments: one dependent on the cellulose synthase complex (CSC), whose density at the plasma membrane positively correlates with resistance to hyperosmotic stress, and the other on remorin (REM), which acts antagonistically to the CSC mechanism. Using proximity-labeling proteomics, we identified SHOU4/4L as REM-associated proteins that mediate this antagonism. Together, our findings reveal how wall-membrane attachments are patterned to mediate plant cell resilience under water stress.
DOI: 10.1016/j.cell.2026.05.009
Source: https://www.cell.com/cell/abstract/S0092-8674(26)00568-4
主题：