覆盖成年猕猴全生命周期的多模态脑细胞图谱

覆盖成年猕猴全生命周期的多模态脑细胞图谱

作者： 小柯机器人 发布时间：2026/8/19 15:09:56

本期文章：《细胞》：Online/在线发表

广东省非人灵长类动物模型研究重点实验室李晓江团队与合作者，成功绘制出成年猕猴一生的多模态脑细胞图谱。这项成果于2026年8月18日发表于《细胞》杂志。

该研究提出了一个全面的转录组学和染色质可及性图谱，来自23只雌性猕猴的8个大脑区域的2,955,873个细胞核，跨越了成年期，包括非常老的个体。他们的分析揭示了动态的、细胞亚型和区域特异性的与年龄相关的核心脑功能变化，包括突触通讯和轴突髓鞘形成。研究人员发现脑桥和脑髓中的多细胞网络是灵长类动物大脑衰老的一个以前未被认识到的热点，突出了白质脆弱性是衰老的一个核心特征。与人类大脑老化和神经变性数据集的整合揭示了共享和不同的分子机制。研究进一步定义了与长寿和神经变性相关的转录因子和年龄相关的染色质重塑程序。这个时空图谱为理解灵长类动物大脑衰老的细胞和调控结构及其与疾病的联系建立了一个基础框架。

研究人员表示，非人类灵长类动物脑组织的高通量单细胞组学为研究脑衰老的分子基础提供了一个强大的平台。

附：英文原文

Title: Multimodal brain cell atlas across the adult macaque lifespan

Author: Xiao Zhang, Guangyao Lai, Xiangyu Guo, Wen Ma, Yue Yuan, Han Zhang, Bo Zhang, Peng Fan, Xingyuan Liu, Pengcheng Guo, Juan An, Jinxiu Li, Keke Huang, Xiaoyan Li, Jing Zuo, Liang Wu, Shuncheng Shangguan, Feng Yu, Yuchen Xiang, Yuebei Hu, Yuxuan Liu, Yunting Huang, Yiting Lin, Dajian He, Mingtian Pan, Laiqiang Chen, Bang Li, Jiawei Zhang, Qintian Guo, Weili Yang, Peng Yin, Shihua Li, Xiaolan Zhang, Tao Yang, Xiaofeng Wei, Yuan Lv, Baoming Qin, Xiaobing Qing, Qiuting Deng, Yaling Huang, Chang Liu, Lei Han, Shiping Liu, Dajiang Qin, Zhen Liu, Yi Zhou, Liang Qiao, Chengyu Li, Yanxiao Zhang, Zunpeng Liu, Yan Li

Issue&Volume: 2026-08-18

Abstract: High-throughput single-cell omics of non-human primate brain tissue provides a powerful platform to investigate the molecular basis of brain aging. Here, we present a comprehensive transcriptomic and chromatin accessibility atlas of 2,955,873 nuclei from eight brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals. Our analyses reveal dynamic, cell-subtype- and region-specific age-related changes in core brain functions, including synaptic communication and axon myelination. We identify multicellular networks in the pons and medulla as a previously unrecognized hotspot of primate brain aging, highlighting white matter vulnerability as a central feature of aging. Integration with human brain aging and neurodegeneration datasets reveals both shared and divergent molecular mechanisms. We further define transcription factors and age-related chromatin remodeling programs linked to longevity and neurodegeneration. This spatiotemporal atlas establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links to disease.

DOI: 10.1016/j.cell.2026.07.045

Source: https://www.cell.com/cell/abstract/S0092-8674(26)00877-9

主题：细胞