帕金森病中的异常伽马振荡
帕金森病中的异常伽马振荡
作者： 小柯机器人 发布时间：2026/9/5 17:35:06
本期文章：《神经科学通报》：Online/在线发表
2026年9月1日，同济大学医学院靳令经教授等科学家在《神经科学通报》发表综述文章，系统总结了帕金森病中异常伽马振荡的临床与临床前证据，并讨论了其潜在机制及治疗干预对其的调控作用。
帕金森病（PD）是第二大常见的神经退行性疾病，目前尚无根治性疗法。在基底节-丘脑皮层环路中，PD以抗动能的beta振荡（13–35 Hz）与促动能的gamma振荡（60–90 Hz）之间的失衡为特征。虽然异常beta活动的病理特征和机制已被广泛研究，但gamma振荡的改变仍了解甚少。新出现的证据表明，不同类型的gamma活动在PD中受到干扰，并与运动障碍、步态障碍和快速眼动睡眠行为障碍等症状相关。本综述总结了当前关于PD中异常gamma振荡的临床和临床前证据，讨论了包括小清蛋白中间神经元功能障碍、基底节环路失衡和神经血管耦合受损在内的潜在机制，并总结了当前PD治疗方法如何调节gamma活动及其对临床结局的潜在影响。
附：英文原文
Title: Aberrant Gamma Oscillations in Parkinson’s Disease
Author: Li, Bing-Yu, Li, Ruo-Yu, Hong, Rong-Hua, Song, Yun-Ping, Jin, Ling-Jing
Issue&Volume: 2026-09-01
Abstract: Parkinson’s disease (PD) is the second-most prevalent neurodegenerative disorder, with no definitive cure currently available. Within the basal ganglia–thalamocortical circuitry, PD is characterized by an imbalance between antikinetic beta oscillations (13–35 Hz) and prokinetic gamma oscillations (60–90 Hz). While the pathological features and mechanisms underlying abnormal beta activity have been extensively studied, alterations in gamma oscillations remain much less well understood. Emerging evidence indicates that different forms of gamma activity are disrupted in PD and associated with symptoms such as dyskinesia, gait impairment, and rapid eye movement (REM) sleep behavior disorder. This review summarizes current clinical and preclinical evidence of aberrant gamma oscillations in PD, discusses underlying mechanisms including parvalbumin interneuron dysfunction, basal ganglia circuit imbalance, and impaired neurovascular coupling, and summarizes how current therapeutic approaches for PD modulate gamma activity and potentially influence clinical outcomes.
DOI: 10.1007/s12264-026-01705-3
Source: https://link.springer.com/article/10.1007/s12264-026-01705-3