F类清道夫受体成员2是乙型肝炎病毒的胞内受体

F类清道夫受体成员2是乙型肝炎病毒的胞内受体

作者： 小柯机器人 发布时间：2026/5/21 15:59:34

本期文章：《细胞》：Online/在线发表

F类清道夫受体成员2是乙型肝炎病毒的胞内受体，这一成果由清华大学李文辉团队经过不懈努力而取得。相关论文于2026年5月20日发表在《细胞》杂志上。

研究小组报道了清道夫受体类成员2 (SCARF2)，一种单遍跨膜蛋白，作为HBV的细胞内受体。SCARF2通过其N端表皮生长因子（EGF）样结构域4-6结合到NTCP结合位点下游的preS1区域，其富含脯氨酸的C端结构域在感染中也起着不可或缺的作用。内化的HBV病毒粒子被转运到含有SCARF2的核孔复合物的细胞质侧。HBV核衣壳从内体囊泡释放受到SCARF2敲低的损害。这些结果表明，SCARF2将HBV传递到核孔复合物（npc）的外围，并最终导致病毒核衣壳释放进入核。

研究人员表示，乙型肝炎病毒（HBV）通过其大包膜蛋白的preS1区域特异性结合细胞表面受体-牛磺酸胆酸钠共转运多肽（NTCP）感染肝细胞，然后通过细胞质到核核的一个不太清楚的转运过程。

附：英文原文

Title: Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus

Author: Cong Li, Yixue Wang, Rui Xiong, Qiaoyi Li, Zhongmin Zhou, Qingmei Liu, Yonghe Qi, Zihao Gao, Guangwei Xu, Linqiang Fang, Yinyan Sun, Michael Farzan, Hyeryun Choe, Jianhua Sui, Wenhui Li

Issue&Volume: 2026-05-20

Abstract: Hepatitis B virus (HBV) infects hepatocytes by specific binding to the cell-surface receptor—sodium taurocholate cotransporting polypeptide (NTCP)—through the preS1 region of its large envelope protein, followed by a less well-understood transport process across the cytoplasm to the nucleus. Here, we report that scavenger receptor class F member 2 (SCARF2), a single-pass transmembrane protein, functions as an intracellular receptor for HBV. SCARF2 binds to a preS1 region downstream of the NTCP binding site through its N-terminal epidermal growth factor (EGF)-like domains 4–6, and its proline-rich C-terminal domain also plays an indispensable role in the infection. The internalized HBV virions are transported to the cytoplasmic side of nuclear pore complexes within the SCARF2-containing endosomes. HBV nucleocapsid release from the endosomal vesicles is impaired by knockdown of SCARF2. These results suggest a model in which SCARF2 conveys HBV to the periphery of nuclear pore complexes (NPCs) and ultimately leads to viral nucleocapsid release for nuclear entry.

DOI: 10.1016/j.cell.2026.04.045

Source: https://www.cell.com/cell/abstract/S0092-8674(26)00512-X

主题：F类清道夫受体成员2