心脏修复中冠状动脉旁支形成的起源
心脏修复中冠状动脉旁支形成的起源
作者： 小柯机器人 发布时间：2026/8/21 10:56:37
本期文章：《科学》：Volume 393 Issue 6813
中国科学院分子细胞科学卓越创新中心周斌团队的一项最新研究揭示了心脏修复中冠状动脉旁支形成的起源。相关论文发表在2026年8月20日出版的《科学》杂志上。
据了解，冠状动脉侧枝被认为是通过动脉重组重新形成的，在这个过程中，动脉内皮细胞（ECs）从先前存在的动脉迁移并重新组装成新的动脉。使用追踪动脉内皮细胞的遗传工具，研究组发现它们对络脉的贡献不大。双遗传谱系追踪显示，毛细血管内皮细胞而不是动脉内皮细胞，是新生侧枝的主要组成部分。毛细血管到侧枝的转换在心脏修复中起着至关重要的作用。
此外，通过修饰的信使RNA瞬时表达Vegfa可显著促进侧枝形成。从机制上讲，血管内皮生长因子（VEGF）通过YY1/SETD1A介导的H3K4三甲基化调节HES1转录，从而驱动动脉化。总的来说，这些发现重新定义了冠状动脉侧枝形成的细胞起源和机制，并强调了其在促进有效心脏修复中的作用。
附：英文原文
Title: Tracing the origins of de novo coronary collateral formation in cardiac repair
Author: Mingjun Zhang, Maoying Han, Yangfeng Hou, Zixin Liu, Yilian Wang, Xiuzhen Huang, Cheng Kiu Ho, Hang Qu, Qing-Dong Wang, Xin Ma, Kathy O. Lui, Bin Zhou
Issue&Volume: 2026-08-20
Abstract: Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble into new arteries. Using genetic tools that trace arterial ECs, we found that their contribution to collaterals is modest. Dual genetic lineage tracing revealed that capillary ECs, rather than arterial ECs, serve as the major building blocks for de novo collaterals. The capillary-to-collateral conversion is functionally crucial for cardiac repair. In addition, transient Vegfa expression through modified messenger RNA markedly promoted collateral formation. Mechanistically, vascular endothelial growth factor (VEGF) drives arterialization by regulating HES1 transcription through YY1/SETD1A-mediated H3K4 trimethylation. Collectively, these findings redefine the cellular origin and mechanism of coronary collateral formation and highlight its role in facilitating efficient cardiac repair.
DOI: ady3027
Source: https://www.science.org/doi/10.1126/science.ady3027