空间生物学揭示免疫抑制非黑色素瘤皮肤癌中巨噬细胞状态的改变
空间生物学揭示免疫抑制非黑色素瘤皮肤癌中巨噬细胞状态的改变
作者： 小柯机器人 发布时间：2026/8/6 15:31:32
本期文章：《细胞》：Online/在线发表
德克萨斯大学Moran Amit课题组近日取得一项新成果。经过不懈努力，他们的最新研究发现，空间生物学揭示了免疫抑制非黑色素瘤皮肤癌中巨噬细胞状态的改变。这一研究成果发表在2026年8月5日出版的国际学术期刊《细胞》上。
通过对免疫活性肿瘤和免疫抑制肿瘤的单细胞、空间转录组、多重免疫荧光和空间表观基因组分析，研究团队发现，尽管免疫细胞分布、空间组织和T细胞克隆性存在差异，但总体免疫细胞组成在很大程度上得到了保留。免疫抑制的肿瘤表现为肿瘤内巨噬细胞密度降低，T细胞克隆多样性降低，抗原呈递细胞和T细胞空间相互作用改变，以及不同的成纤维细胞和巨噬细胞相关的空间生态位。在互补空间和单细胞平台上的多队列验证确定了免疫抑制肿瘤中先天适应性免疫组织的一致改变。总之，这些发现定义了系统性免疫抑制下肿瘤免疫微环境的空间和功能重塑，并为未来高风险患者的治疗研究提供了框架。
研究人员表示，免疫抑制的非黑色素瘤皮肤癌患者的临床结果更差，然而与全身免疫抑制相关的肿瘤免疫微环境仍然不完全确定。
附：英文原文
Title: Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer
Author: Shorook Naara, Veena Kochat, Xiayu Rao, Emre Arslan, Robert Saddawi-Konefka, Suresh Satpati, Jennifer Garbarino, Jennifer L. Anderson, Frederico O. Gleber-Netto, Priyadharsini Nagarajan, Travis D. Kerr, Shamima Akhter, Sophie Li, R’ay Fodor, Shlomo A. Koyfman, Dan Yaniv, Tongxin Xie, Mica Glaun, Michael Bobian, William Israel Padron, Colin Ng, Preethi H. Gunaratne, Shiyanth Thevasagayampillai, Michael R. Migden, Hussein A. Abbas, Patrick K. Reville, Kenneth Y. Tsai, Daniel J. McGrail, Jing Wang, Jeffrey N. Myers, Neil D. Gross, Kunal Rai, Moran Amit
Issue&Volume: 2026-08-05
Abstract: Immunosuppressed patients with non-melanoma skin cancer experience worse clinical outcomes, yet the tumor immune microenvironment associated with systemic immunosuppression remains incompletely defined. Using integrated single-cell, spatial transcriptomic, multiplex immunofluorescence, and spatial epigenomic profiling across immunocompetent and immunosuppressed tumors, we found that overall immune-cell composition was largely preserved despite differences in immune-cell distribution, spatial organization, and T cell clonality. Immunosuppressed tumors demonstrated reduced intratumoral macrophage densities, decreased T cell clonal diversity, altered antigen-presenting cell and T cell spatial interactions, and distinct fibroblast- and macrophage-associated spatial niches. Multi-cohort validation across complementary spatial and single-cell platforms identified consistent alterations in innate-adaptive immune organization in immunosuppressed tumors. Together, these findings define spatial and functional remodeling of the tumor immune microenvironment under systemic immunosuppression and provide a framework for future therapeutic investigation in high-risk patients.
DOI: 10.1016/j.cell.2026.07.031
Source: https://www.cell.com/cell/abstract/S0092-8674(26)00863-9