研究发现人类寿命的白质微观和宏观结构脑图
研究发现人类寿命的白质微观和宏观结构脑图
作者： 小柯机器人 发布时间：2026/5/14 17:29:10
本期文章：《自然》：Online/在线发表
范德比尔特大学Kurt G. Schilling小组取得一项新突破。他们的研究发现人类寿命的白质微观和宏观结构脑图。该研究于2026年5月13日发表于国际一流学术期刊《自然》杂志上。
如果研究人员希望在临床上利用这些白质结构生物标志物，建立一个现成的规范性参考是必不可少的第一步。
这里该课题组人员给出了人类大脑白质的寿命参考图表。通过处理和标准化来自不同全球研究的35,120个脑部扫描，该研究组绘制了从出生到100岁的特定大脑通路的典型生长、成熟和年龄相关衰退。这些参考图表建立了健康大脑发育和衰老的基本基准，使研究人员和临床医生能够量化个体大脑如何偏离典型模式，并突出显示与疾病相关的改变。
此外，随附的开放获取图表使科学和临床社区能够根据这些规范基线评估新的患者和研究数据，促进未来的临床和神经科学研究。
据介绍，人类大脑的功能依赖于一个复杂的连接网络，而白质是大脑不同区域之间的主要通讯通道。这些关键的沟通途径的中断与几种神经、精神和发育障碍有关。尽管临床医生长期以来一直以标准生长图表为主题来跟踪身体发育，但随着最近的研究将这些图表转化为全脑和灰质测量，白质还没有相应的参考标准。
附：英文原文
Title: White matter micro- and macrostructure brain charts for the human lifespan
Author: Kim, Michael E., Gao, Chenyu, Ramadass, Karthik, Newlin, Nancy R., Kanakaraj, Praitayini, Bogdanov, Sam, Rudravaram, Gaurav, Archer, Derek, Hohman, Timothy J., Jefferson, Angela L., Morgan, Victoria L., Roche, Alexandra, Englot, Dario J., Resnick, Susan M., Beason-Held, Lori L., Cutting, Laurie E., Barquero, Laura A., Darchangel, Micah A., Nguyen, Tin Q., Humphreys, Kathryn L., Niu, Yanbin, Vinci-Booher, Sophia, Cascio, Carissa J., Davis, L. Taylor, Li, Zhiyuan, Vandekar, Simon N., Zhang, Panpan, Gore, John C., Landman, Bennett A., Schilling, Kurt G.
Issue&Volume: 2026-05-13
Abstract: The human brain relies on a complex network of connections to function, with white matter acting as the primary communication highway between different brain regions1,2. Disruptions in these critical communication pathways are linked to several neurological, psychiatric and developmental disorders3,4. Although clinicians have long used standard growth charts to track physical development5, with more recent work translating these to whole-brain and grey matter measurements6,7,8,9, there has been no equivalent reference standard for white matter. Establishing a readily available normative reference is an imperative first step if we hope to utilize these white matter structural biomarkers clinically. Here we present lifespan reference charts for human brain white matter. By processing and standardizing 35,120 brain scans from diverse global studies, we mapped the typical growth, maturation and age-related decline of specific brain pathways from birth to 100 years of age. These reference charts establish a fundamental benchmark for healthy brain development and ageing, allowing researchers and clinicians to quantify how an individual’s brain deviates from typical patterns and highlighting disorder-related alterations. Furthermore, the accompanying open access charts enable the scientific and clinical communities to evaluate new patient and research data against these normative baselines, facilitating future clinical and neuroscience studies.
DOI: 10.1038/s41586-026-10454-2
Source: https://www.nature.com/articles/s41586-026-10454-2